Comparison 2. Minocycline ER versus placebo.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Percentage change in inflamed lesion counts	3	1038	Mean Difference (IV, Fixed, 95% CI)	13.43 [7.10, 19.76]
2 Percentage change in total lesion counts	3	1038	Mean Difference (IV, Fixed, 95% CI)	9.84 [4.84, 14.84]
3 Investigator global severity ‐ successful treatment	2	924	Risk Ratio (M‐H, Fixed, 95% CI)	1.90 [1.27, 2.84]
4 Clear or almost clear 12 weeks	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
4.1 3 mg versus placebo	1		Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
4.2 2 mg versus placebo	1		Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
4.3 1 mg versus placebo	1		Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
4.4 Pooled	1		Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]