Comparison 4. Minocycline 100 mg od versus 100 mg/50 mg od.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Lesion counts ‐ reduction from baseline after 60 days therapy	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
1.1 Non‐inflamed: intention‐to‐treat analysis	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
1.2 Non‐inflamed lesions: per‐protocol analysis	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
1.3 Inflamed lesions: intention‐to‐treat analysis	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
1.4 Inflamed lesions: per‐protocol analysis	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
1.5 Total lesions: intention‐to‐treat analysis	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
1.6 Total lesions: per‐protocol analysis	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
2 Overall clinical improvement ‐ dr‐assessed	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
2.1 Any improvement: intention‐to‐treat analysis	1		Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
2.2 Any improvement: per‐protocol analysis	1		Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
2.3 Any improvement: worse‐case analysis	1		Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
2.4 Moderate or excellent improvement: intention‐to‐treat analysis	1		Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
2.5 Moderate or excellent improvement: per‐protocol analysis	1		Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
2.6 Moderate or excellent improvement: worse‐case analysis	1		Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
3 Participant evaluations ‐ 10 cm visual analogue scales	1		Mean Difference (IV, Fixed, 95% CI)	Totals not selected
3.1 Overall efficacy: intention‐to‐treat analysis	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
3.2 Overall efficacy: per‐protocol analysis	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
3.3 Importance of acne ‐ change from baseline: intention‐to‐treat analysis	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
3.4 Importance of acne ‐ change from baseline: per‐protocol analysis	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
3.5 Impact on relationships ‐ change from baseline: intention‐to‐treat analysis	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
3.6 Impact on relationships ‐ change from baseline: per‐protocol analysis	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
3.7 Impact on sexual relationships ‐ change from baseline: intention‐to‐treat analysis	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
3.8 Impact on sexual relationships ‐ change from baseline: per‐protocol analysis	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
3.9 Impact on physical appearance ‐ change from baseline: intention‐to‐treat analysis	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]
3.10 Impact on physical appearance ‐ change from baseline: per‐protocol analysis	1		Mean Difference (IV, Fixed, 95% CI)	0.0 [0.0, 0.0]