Comparison 8. Minocycline 100 mg/200 mg per day versus josamycin 500 mg/1000 mg.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Pustules change in P&K severity grade 8 weeks	1	122	Mean Difference (IV, Fixed, 95% CI)	0.30 [0.07, 0.53]
2 Nodulo‐cysts change in P&K severity grade 8 weeks	1	122	Mean Difference (IV, Fixed, 95% CI)	0.40 [0.20, 0.60]
3 Erythema change in severity score 8 weeks	1	122	Mean Difference (IV, Fixed, 95% CI)	0.30 [0.12, 0.48]
4 Seborrhea change in severity score 8 weeks	1	122	Mean Difference (IV, Fixed, 95% CI)	0.40 [0.22, 0.58]
5 Evaluation of clinical efficacy 8 weeks	1		Risk Ratio (M‐H, Fixed, 95% CI)	Totals not selected
5.1 Markedly effective	1		Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
5.2 Effective	1		Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
5.3 Moderately effective	1		Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
5.4 Combined effective or markedly effective	1		Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]
5.5 Ineffective	1		Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]