Comparison 11. Minocycline 100 mg daily versus zinc gluconate 30 mg bd.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Lesion count ‐ percentage change from baseline 90 days	1	318	Mean Difference (IV, Fixed, 95% CI)	‐16.42 [‐25.10, ‐7.74]
1.1 Inflamed lesion counts ‐ papules pustules	1	318	Mean Difference (IV, Fixed, 95% CI)	‐16.42 [‐25.10, ‐7.74]
2 Investigator global severity ‐ successful treatment (2/3 reduction in IL)	1	318	Risk Ratio (M‐H, Fixed, 95% CI)	2.03 [1.56, 2.63]
3 Overall opinion on efficacy (100 mm VAS)	1		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
3.1 Clinician‐assessed	1	307	Mean Difference (IV, Fixed, 95% CI)	13.70 [7.67, 19.73]
3.2 Participant‐assessed	1	296	Mean Difference (IV, Fixed, 95% CI)	16.70 [10.68, 22.72]