Pelfini 1989.
Methods |
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Participants | 122 participants were enrolled.
61 participants were randomised in the minocycline group, and 61 participants were randomised in the josamycin group.
There was 1 dropout (minocycline participant).
The mean age was 21.3 in the minocycline group (range = 14 to 34) and 20.3 in the josamycin group (range = 14 to 33).
Participants were recruited from the university dermatology departments. Inclusion criteria of the trial
Exclusion criteria of the trial
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Interventions |
Concomitant therapy: "In 69 patients, 35 in the josamycin group, 34 in the minocycline group, the clinical presentation suggested the association of a topical medication 5% benzoyl peroxide ointment to the oral treatment." Appearance: standard Instructions: orally once‐daily for 2 months Skin hygiene: no details Empty stomach: no details Compliance: no details |
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Outcomes |
Outcomes of the trial
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Notes | Country: Italy Language: English Review version: 2012 35/61 josamycin participants and 34/61 minocycline participants suggested concomitant use of 5% benzoyl peroxide treatment at presentation. There was concomitant use of benzoyl peroxide in some participants. There were 2 different regimens, and it was unclear how participants were allocated to each. This was a very poor trial write‐up due to the English not being the first language of the authors. |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | High risk | Quote: "...randomly allocated." Comment: The report suggests that a number of participants were also given 5% benzoyl peroxide, which is very active. These were not randomised. Also, there were 2 different treatments schedules, and it was unclear how they were randomised (possibly based on severity). |
Allocation concealment (selection bias) | Unclear risk | This was unclear; no details were given. |
Blinding (performance bias and detection bias) All outcomes | High risk | 'Previous open studies...' was stated, implying that this was also open. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | 1/61 participants discontinued in the minocycline group due to severe gastric intolerance. It appears all other participants provided data. |
Selective reporting (reporting bias) | Low risk | All prespecified outcomes were reported. The results were presented graphically only. |