Sheehan‐Dare 1989.
Methods |
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Participants | 66 participants were enrolled.
33 participants were randomised to the minocycline group; 33 participants were randomised to the clindamycin group.
There was 1 (6%) dropout in the minocycline group and 6 (18%) in the clindamycin group.
The age range was 14 to 35.
Recruitment was fulfilled by hospital out‐patients. There was baseline comparability (age, sex, grade, and count). Inclusion criteria of the trial
Exclusion criteria of the trial
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Interventions |
Appearance: standard but double‐dummy used Concomitant therapy: not specified Instructions: capsules to be taken before meals, apply lotion to whole face Skin hygiene: not specified Empty stomach: not specified Compliance: not specified |
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Outcomes |
Outcomes of the trial
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Notes | Country: United Kingdom
Language: English Review version: 2002 Data were presented in graphical form only. Macules were included in the ILC. Grades and counts were log transformed prior to analysis. The manufacturers or authors couldn't supply further information. The numbers of participants in each group were not reported. There were differences between the 2 reports of the same trial, including whether or not there was a statistically significant reduction in non‐inflamed lesion counts, and in the type of statistical tests used. There were differences between 2 publications of this trial. |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Randomisation was stated to be by matched pairs on the basis of age, sex, acne grade, and numbers of both inflamed and non‐inflamed lesions, but no details were given about the method of sequence generation. |
Allocation concealment (selection bias) | Unclear risk | This was unclear; no details were given. |
Blinding (performance bias and detection bias) All outcomes | Low risk | It was stated to be "double blind, double dummy" (page 25 of the published report). No further details were given. |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | 66 participants were enrolled, but there were no details on how many participants were randomised to each group: It was assumed to be 33 due to matched pairs. 6 dropped out from the clindamycin arm and 1 from the minocycline arm, but it was unclear at which time point these dropouts occurred. |
Selective reporting (reporting bias) | Low risk | All outcomes, including adverse events, were reported at each time point. No data were reported (graphical only). |