Escorsell 2000.
Methods | Randomised: yes, by computer generated sequence . Concealment: sealed and opaque envelopes . Double‐blind: no. Description of withdrawals/dropouts: yes. Length of FU: 42 days. Jadad score: 3/5 | |
Participants | Country: France, Spain. Diagnosis of bleeding: by endoscopy. Source of bleeding: all confirmed or unconfirmed varices. Endoscopy in all patients prior to randomisation on average five hr after admission. Diagnosis of cirrhosis: histological or clinical. 219 patients with 219 admissions. Child's A = 20% B = 50% C = 30%. Alcoholic cirrhosis = 40%. | |
Interventions | Terlipressin versus sclerotherapy. R x 1: terlipressin 2 mg iv every 4 h until control of bleeding then 1mg evert 4 h for another five days. R x 2: sclerotherapy. Time from admission to treatment: 6.1 h. Initial sclerotherapy: not relevant. |
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Outcomes | 1. Mortality at 42 days. 2. Failure of initial haemostasis at 48 h. 3. Rebleeding at 42 days. 4. Procedures required for haemostasis. 5. Blood transfusions. 6. LOS. | |
Notes | Source of funding: (?) | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment? | Low risk | A ‐ Adequate |