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. 2003 Jan 20;2003(1):CD002147. doi: 10.1002/14651858.CD002147

Freeman 1989.

Methods Randomised: yes, but method not described. 
 Concealment: method not described. 
 Double‐blind: yes. Adequate method with identical placebo described. 
 Description of withdrawals/drop‐outs: no. 
 Length of FU: until discharge. 
 Jadad score: 3/5.
Participants Country: U.K. 
 Diagnosis of bleeding: by endoscopy. 
 Source of bleeding: all confirmed varices. 
 Endoscopy performed in all patients prior to randomisation. 
 Diagnosis of cirrhosis: clinical. 
 29 patients with 31 bleeding episodes. 
 Child's A = 48%, B = 23%, C = 29%. 
 Alcoholic cirrhosis = 77%.
Interventions Terlipressin versus 
 placebo.
Rx:terlipressin 2 mg iv every 4 h for 24 h or until bleeding stopped. Then 1 mg iv every 4 h for another 24 h. 
 Control: placebo.
Time from admission to treatment: within four hours.
Initial sclerotherapy: not done.
Outcomes 1. Mortality at discharge. 
 2. Failure of initial haemostasis. 
 3. Rebleeding at discharge. 
 4. Procedures required for haemostasis. 
 5. Blood transfusions. (median and range) 
 6. LOS: NR.
Notes Source of funding: unknown.
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Unclear risk B ‐ Unclear