Freeman 1989.
Methods | Randomised: yes, but method not described. Concealment: method not described. Double‐blind: yes. Adequate method with identical placebo described. Description of withdrawals/drop‐outs: no. Length of FU: until discharge. Jadad score: 3/5. | |
Participants | Country: U.K. Diagnosis of bleeding: by endoscopy. Source of bleeding: all confirmed varices. Endoscopy performed in all patients prior to randomisation. Diagnosis of cirrhosis: clinical. 29 patients with 31 bleeding episodes. Child's A = 48%, B = 23%, C = 29%. Alcoholic cirrhosis = 77%. | |
Interventions | Terlipressin versus
placebo. Rx:terlipressin 2 mg iv every 4 h for 24 h or until bleeding stopped. Then 1 mg iv every 4 h for another 24 h. Control: placebo. Time from admission to treatment: within four hours. Initial sclerotherapy: not done. |
|
Outcomes | 1. Mortality at discharge. 2. Failure of initial haemostasis. 3. Rebleeding at discharge. 4. Procedures required for haemostasis. 5. Blood transfusions. (median and range) 6. LOS: NR. | |
Notes | Source of funding: unknown. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment? | Unclear risk | B ‐ Unclear |