Muraro 1995.

Methods	Randomized, parallel, single‐blind, controlled study.
Participants	N=20; Geographic region: Italy Mean age: 42.5 Discontinuations/Not available to follow‐up: none reported
Interventions	Seaprose S (a proteolytic enzyme reported to have anti‐inflammatory action) 30 mg + hyperthermia (combo)(n=10) vs. Hyperthermia (mono) [1 hr session x 7 each; 42.5 ‐ 43.5C] (n=10). Study duration: 2 weeks
Outcomes	Symptomatic changes; Instrumental tests (uroflowmetry; transurethral prostatic echography).
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Unclear risk	B ‐ Unclear