. 2019 Aug 29;10(41):9506–9512. doi: 10.1039/c9sc04028e

Table 1. Oxime ligation conversions (%) determined by LCMS after 24 h.


Entry	Peptides	% Oxime at t = 24 h
1	2a: R¹ = H, R² = NMe₂	>99 ^a
2	2b: R¹ = CH₃, R² = NMe₂	94 ^a
3	2c: R¹ = Ph, R² = NMe₂	99 ^a
4	2d: R¹ = CH₂Ph, R² = NMe₂	69 ^a
5	3a: R¹ = H, R² = OMe	<1 ^a (72 ^b )
6	3b: R¹ = CH₃, R² = OMe	<1 ^a (<1 ^b )
7	3c: R¹ = Ph, R² = OMe	<1 ^a (<1 ^b )
8	3d: R¹ = CH₂Ph, R² = OMe	<1 ^a (<1 ^b )

^aReactions were performed in phosphate buffer pH 7 under an O₂ atmosphere with 5 mM O-benzylhydroxylamine hydrochloride and 1 mM peptide concentrations.

^bReactions were performed in ammonium acetate buffer pH 4.5 under air with 1 mM O-benzylhydroxylamine hydrochloride and 1 mM peptide concentrations.13