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. Author manuscript; available in PMC: 2020 Feb 13.
Published in final edited form as: Heart Rhythm. 2018 Apr 3;15(8):1233–1241. doi: 10.1016/j.hrthm.2018.03.041

Figure 2. Acute Pak1 inhibition increases atrial arrhythmic events.

Figure 2

Examples of left atrial electrograms showing spontaneous activity (SR: sinus rhythm) and burst pacing (burst) induced arrhythmia in WT (A), Pak1−/− (B), and WT hearts perfused with IPA-3 (10 µmol/L) (C). (D) Percent of burst pacing episodes that induced arrhythmic events in Pak1−/− and WT hearts during Ctrl conditions, treatment with IPA-3, or FTY720 (1 µmol/L). (*p < 0.05).