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. Author manuscript; available in PMC: 2020 Feb 13.
Published in final edited form as: Heart Rhythm. 2018 Apr 3;15(8):1233–1241. doi: 10.1016/j.hrthm.2018.03.041

Fig. 7. Pak1 stimulation prevents arrhythmic events in AMs from a canine AF model.

Fig. 7

(A) Field stimulation-induced Ca2+ transients in VT-AMs before and 20 min after AngII stimulation under Ctrl conditions (black) and in presence of FTY720 (200 nmol/L; grey). Bar graphs show percent change in (B) diastolic [Ca2+]i, Ca2+ transient amplitude (C) and decay constant (τCa,(D)) after AngII stimulation under Ctrl conditions and in presence of FTY720. (E) Mean number of spontaneous Ca2+ transients (events/s) in VT-AMs under indicated treatment conditions (*: p < 0.05 compared to Ctrl, #: p< 0.05 compared to VT-AMs+AngII).