. Author manuscript; available in PMC: 2020 Dec 1.

Published in final edited form as: Regul Toxicol Pharmacol. 2019 Sep 30;109:104483. doi: 10.1016/j.yrtph.2019.104483

Table 1.

Rat study design

Group	Dose (mg/kg/day)	Formulation Concentration (mg/mL)	Number of Rats
			Core^a/Recovery^b Cohort		TK Cohort

			M	F	M	F
1- Control	0	0	10	10	3	3
2- Low Dose	10	1	10	10	9	9
3- Mid Dose	40	4	10	10	9	9
4- High Dose^c	150	15	10	10	9	9

^a.

Core Groups (5 rats/sex/dose) Necropsy Day = Day 35

^b.

Dosing discontinued on Day 35. Recovery Groups (5 rats/sex/dose) Necropsy Day = Day 57

^c.

The 150 mg/kg/day dose was the maximum feasible dose based on the solubility of JD5037 in the vehicle.