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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Regul Toxicol Pharmacol. 2019 Sep 30;109:104483. doi: 10.1016/j.yrtph.2019.104483

Table 3.

Cmax and AUClast values in rats on Day 1 and Day 34

Sex Dose (mg/kg) Cmax (ng/mL) Dose Normalized Cmax [(ng/mL)/(mg/kg)] AUClast (hr*ng /mL) Dose Normalized AUClast [(hr*ng/mL)/(mg/kg)] Tmax (hr)
Day 1 Day 34 Day 1 Day 34 Day 1 Day 34 Day 1 Day 34 Day 1 Day 34
Male 10 784 1300 78 130 6840 9720 684 972 8.0 8.0
40 1060 1240 27 31 8470 10300 212 258 4.0 4.0
150 1060 691 7 5 9700 6770 65 45 4.0 2.0
Female 10 1260 2700 126 270 21300 30700 2130 3070 12.0 8.0
40 3080 2130 77 53 37200 28600 930 715 4.0 8.0
150 2350 1720 16 11 24800 20600 165 137 4.0 8.0