. Author manuscript; available in PMC: 2020 Dec 1.

Published in final edited form as: Regul Toxicol Pharmacol. 2019 Sep 30;109:104483. doi: 10.1016/j.yrtph.2019.104483

Table 5.

Toxicokinetics of JD5037 in dogs- Day 28

Dose (mg/kg)	Sex		C_max (ng/mL)	C_max/Dose (ng/mL)/(mg/kg)	T_max (hr)	Elimination Half-Life (hr)	Apparent Clearance (mL/hr/kg)	Apparent Volume of Distribution (mL/kg)	AUC_last (hr*ng/mL)	AUC_∞ (hr*ng/mL)	AUC_∞/Dose (hr*ng/mL)/(mg/kg)
5 mg/kg	Male	Mean	221	44.2	2.40	11.4	1840	26300	2650	3460	691
		SE	39	7.9	0.68	2.7	510	5500	540	700	140
	Female	Mean	525	105	4.40	6.84	2010	18500	4940	4930	986
		SE	139	28	0.98	1.12	850	7700	1450	1980	396
20 mg/kg	Male	Mean	373	18.6	3.20	9.85	4300	60700	4250	5250	262
		SE	29	1.5	0.49	1.04	810	13800	580	830	42
	Female	Mean	280	14.0	3.40	7.34	6120	60300	3340	3890	195
		SE	39	1.9	0.60	1.22	1180	10900	590	880	44
75 mg/kg	Male	Mean	284	3.78	2.00	12.3	18900	320000	3220	4370	58.3
		SE	46	0.61	0.71	2.4	3200	54000	480	800	10.6
	Female	Mean	243	3.24	3.10	10.4	27400	392000	2680	2810	37.5
		SE	52	0.70	1.36	2.0	2500	46000	490	260	3.4
20 mg/kg (Fed)	Male	Mean	927	46.4	4.00	16.5	837	20000	14900	24100	1200
		SE	NA	NA	NA	NA	NA	NA	NA	NA	NA
	Female	Mean	996	49.8	4.00	7.69	1200	13700	14900	17100	854
		SE	NA	NA	NA	NA	NA	NA	NA	NA	NA