. Author manuscript; available in PMC: 2020 Dec 1.

Published in final edited form as: Regul Toxicol Pharmacol. 2019 Sep 30;109:104483. doi: 10.1016/j.yrtph.2019.104483

Table 9.

Microscopic findings in dogs at the end of recovery period.

Tissue	Microscopic Observation	Male				Female

		0 mg/kg N=2	5 mg/kg N=2	20 mg/kg N=2	75 mg/kg N=2	0 mg/kg N=2	5 mg/kg N=2	20 mg/kg N=2	75 mg/kg N=2
	AUC_last (hr*ng/mL) on Day 28	0	2650	4250	3220	0	4940	3340	2680

Duodenum	Chronic-active inflammation
	Minimal	0	0	0	0	0	0	0	0
Jejunum	Lymphoid tissue hyperplasia
	Minimal	1	0	1	1	0	0	0	0
	Chronic-active inflammation
	Minimal	0	0	0	0	0	0	0	0
Ileum	Lymphoid tissue hyperplasia
	Minimal	1	0	2	0	0	0	0	0
	Mild	0	0	0	1	0	0	0	0
	Chronic-active inflammation
	Minimal	0	0	0	0	0	0	0	0
Colon	Lymphoid tissue hyperplasia
	Minimal	0	0	0	0	0	0	0	0
Pancreas	Single cell necrosis
	Minimal	0	0	0	0	0	0	0	0
Thymus	Cortical Atrophy
	Minimal	0	0	0	0	0	0	0	0
	Mild	0	1	0	0	0	0	0	0
	Moderate	0	0	0	0	0	0	0	0

The numbers indicate number of animals affected in the group