Table 4.
Summary of parameters for intravenous antibody infusion.
| Parameter | Description | Value | Units | Ref. |
|---|---|---|---|---|
| KD(V•AB) | Binding affinity for VEGF to AB | 2.2 | nM | 46, 72 |
| kon(V•AB) | on-rate constant for V•AB | 9.2×104 | M−1s−1 | 46 |
| koff(V•AB) | off-rate constant for V•AB | 2.0×10”4 | s−1 | 46 |
| kperm(AB) | vascular permeability of AB | 3×10−8 | cm/s | 46 |
| kperm(V•AB) | vascular permeability of V•AB | 3×10−8 | cm/s | 46 |
| klymph(AB), MBM | lymphatic drainage of AB from MBM | 0.1418 | cm2/s | 68 |
| klymph(V•AB), MBM | lymphatic drainage of V•AB from MBM | 0.1418 | cm2/s | 68 |
| klymph(AB), PCM | lymphatic drainage of AB from PCM | 0.0022 | cm2/s | 68 |
| klymph(V•AB), PCM | lymphatic drainage of V•AB from PCM | 0.0022 | cm2/s | 68 |
| kCL(AB) | clearance of AB from blood | 3.2×10−7 | s−1 | 46 |
| kCL(V•AB) | clearance of V•AB from blood | 3.2×10−7 | s−1 | 46 |
| Bolus size | dose (70kg human subject) | 10 | mg/kg | 46 |
| Infusion duration | 90 | min | 46 | |
Notes: (1) All parameters assumed same for Anti-VEGF and Anti-VEGF165b, aside from set of VEGF isoforms bound by ligand. (2) MBM = main body mass, PCM = PAD calf muscle