Comparison 1. Vancomycin versus control.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Incidence of sepsis (all pathogens); number of patients with one or more episodes	4	290	Risk Ratio (M‐H, Fixed, 95% CI)	0.11 [0.05, 0.24]
1.1 Continuous vancomycin infusion	3	249	Risk Ratio (M‐H, Fixed, 95% CI)	0.09 [0.03, 0.23]
1.2 Intermittent vancomycin treatment	1	41	Risk Ratio (M‐H, Fixed, 95% CI)	0.21 [0.05, 0.84]
2 Incidence of CoNS sepsis; number of patients with one or more episodes	4	221	Risk Ratio (M‐H, Fixed, 95% CI)	0.33 [0.19, 0.59]
2.1 Continuous vancomycin infusion	2	108	Risk Ratio (M‐H, Fixed, 95% CI)	0.07 [0.01, 0.52]
2.2 Intermittent vancomycin treatment	2	113	Risk Ratio (M‐H, Fixed, 95% CI)	0.49 [0.27, 0.90]
3 Mortality prior to hospital discharge	4	330	Risk Ratio (M‐H, Fixed, 95% CI)	0.79 [0.40, 1.58]
3.1 Continuous vancomycin infusion	3	258	Risk Ratio (M‐H, Fixed, 95% CI)	0.76 [0.35, 1.63]
3.2 Intermittent vancomycin treatment	1	72	Risk Ratio (M‐H, Fixed, 95% CI)	0.95 [0.20, 4.38]
4 Length of NICU stay (days)	1	70	Mean Difference (IV, Fixed, 95% CI)	5.0 [‐24.65, 34.65]
4.1 Continuous vancomycin infusion	1	70	Mean Difference (IV, Fixed, 95% CI)	5.0 [‐24.65, 34.65]
5 Hearing impairment (auditory brainstem evoked response)	2	211	Risk Ratio (M‐H, Fixed, 95% CI)	0.33 [0.05, 2.07]