| Allocation: randomised, block, fully explicit description..
Duration: 2 weeks. |
Diagnosis: not prestipulated, acute agression thought to be due to serious mental illness.
N=300.*
Age: adults.
Sex: both. |
1. Loxapine: dose 25‐50 mg/6‐12 hours IM. N=150.
2. Haloperidol + promethazine: dose 5‐10mg, 25‐50 mg IM stat. N=150. |
Tranquil by 20, 40, 60, 90, 180 mins.
Need for further medication.
Need to call doctor again.
Time in restraints.
General functioning.
Behaviour.
Symptoms.
Adverse events.
Satisfaction with care.
Economic outcomes. |
* powered to be able to identify a difference of ˜20% between groups for primary outcome with adequate degree of certainty. |
