Clark 1972.

Methods	Allocation: random, stratified age and sex. Blinding: double blind‐identical capsules. Duration: 12 weeks, with 12 weeks washout.
Participants	Diagnosis: schizophrenia, confirmed by project psychiatrist. N=55. Age: 21‐60 years. Sex: 31 M, 24 F. History: inpatients, ill for at least 2 years.
Interventions	1. Loxapine: dose 10 mg/day increased to 100 mg/day in 25 days. N=18 2. Chlorpromazine: dose 100 mg/day increased to 1gm/day . N=19. 3. Placebo. N=18. Antiparkinsonian medication allowed as required.
Outcomes	Global effect: CGI (improvement). Adverse effects(physical examination, lab results, ECG and eye examination). Unable to use ‐ Global effect: CGI (severity) (no SD). Mental state: BPRS (no SD). Behaviour: NOSIE (no SD).
Notes	Weight increase or decrease ‐ 10 lbs. All blood test abnormalities combined. For CGI (improvement) reading by psychiatrist 2 used (randomly chosen by lots).
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Unclear risk	B ‐ Unclear