Seth 1979.

Methods	Allocation: random ‐ no further details. Blinding: double ‐ identical capsules. Duration: 12 weeks ‐ preceded by 4 week washout period. Setting: single centre.
Participants	Diagnosis: schizophrenia, chronic (by 2 psychiatrists). N=72. Age: mean ˜ 30 years, range <20‐49. Sex: 28 M, 36 F, 8 not reported. History: hospitalised patients. Exclusion: ill health, pregnant or risk of, substance abuse.
Interventions	1. Loxapine: dose 20‐90 mg/day. N=36. 2. Trifluoperazine: dose 5‐45 mg/day. N=36.
Outcomes	Leaving the study early. Dropped from analysis. Adverse effects. Unable to use ‐ Global effect: CGI (no usable data). Mental state: BPRS (no usable data). Behaviour: NOSIE (no usable data). Physiological measures: BP, ECG, ophthalmic tests, pulse, temperature, weight (no data). Laboratory tests: (no data).
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Unclear risk	B ‐ Unclear