Table 2. List of putative urine biomarkers derived from the training data set.
The selected seven urine metabolites were the only compounds in this study which met the following inclusion criteria: MDA ≥ 0.004, VIP score > 1.0, ROC AUC > 0.85 and in at least one treatment time-point.
| Time 2 | MDA | VIP score | ROC AUC |
| Tryptophan | 1.20% | 1.7 | 1.0 |
| Taurine | 1.19% | 1.6 | 1.0 |
| Threonic acid | 1.11% | 1.5 | 1.0 |
| Tyrosine | 0.36% | 1.4 | 0.93 |
| Lyxitol | 0.23% | 1.4 | 0.93 |
| Xylitol | 0.38% | 1.4 | 0.93 |
| Pseudouridine | 0.35% | 1.3 | 0.9 |
| Time 3 | MDA | VIP score | ROC AUC |
| Tryptophan | 0.52% | 1.6 | 0.9 |
| Taurine | 1.21% | 2.0 | 1.0 |
| Threonic acid | 0.00% | 1.3 | 0.9 |
| Tyrosine | 0.17% | 1.6 | 0.93 |
| Lyxitol | 1.15% | 1.9 | 1.0 |
| Xylitol | 0.16% | 1.2 | 0.97 |
| Pseudouridine | 1.77% | 1.9 | 1.0 |
| Time 4 | MDA | VIP score | ROC AUC |
| Tryptophan | 0.44% | 1.5 | 0.97 |
| Taurine | 0.46% | 1.4 | 0.93 |
| Threonic acid | 0.61% | 1.4 | 0.97 |
| Tyrosine | 1.31% | 1.8 | 1.0 |
| Lyxitol | 1.47% | 1.6 | 1.0 |
| Xylitol | 0.52% | 1.5 | 0.93 |
| Pseudouridine | 0.31% | 1.2 | 0.93 |
| Time 5 | MDA | VIP score | ROC AUC |
| Tryptophan | -0.07% | 1.2 | 0.9 |
| Taurine | 0.40% | 1.5 | 0.93 |
| Threonic acid | -0.23% | 1.3 | 0.87 |
| Tyrosine | 2.85% | 2.1 | 1.0 |
| Lyxitol | 0.33% | 1.5 | 0.9 |
| Xylitol | 0.08% | 1.4 | 0.87 |
| Pseudouridine | 0.58% | 1.6 | 0.9 |