Table 1.
Characteristics of community-onset UTI caused by ESBL-producing Escherichia coli.
| ESBL-positive E. coli, n=154 (%) | ESBL-negative E. coli, n=151 (%) | P-value | |
| Sex, male, n = 116 (%) | 73 (47.4) | 43 (28.5) | 0.01 |
| Age ≥55 years | 101 (65.6) | 78 (51.7) | 0.014 |
| Hospitalization within 6 monthsLength of hospital stay, days, mean ± SD | 73 (47.4)16.86 ± 18.07 | 22 (14.6)15.95 ± 15.71 | <0.00010.83 |
| Use of antibiotics within previous 6 monthsFluoroquinolonesCephalosporinsBeta-lactam-beta-lactamase inhibitors | 62 (40.3)24 (16.0)28 (18.3)6 (3.9) | 20 (13.2)11 (7.3)6 (4.0)2 (1.3) | <0.00010.019<0.0010.16 |
| Healthcare-associated UTI | 98 (63.6) | 44 (29.1) | <0.0001 |
| Upper UTI | 94 (61.0) | 36 (23.8) | <0.0001 |
| Frequent UTIs (>3 times/year) | 45 (29.2) | 16 (10.6) | <0.0001 |
| Indwelling urethral catheter | 75 (48.7) | 30 (19.9) | <0.0001 |
| Diabetes mellitus | 41 (26.6) | 45 (29.8) | 0.53 |
| Renal failure | 54 (35.1) | 23 (15.2) | <0.0001 |
| Nephrolithiasis | 28 (18.2) | 25 (16.6 | 0.708 |
| Renal transplantation | 6 (3.9) | 2 (1.3) | 0.160 |
| Use of corticosteroid | 11 (7.1) | 10 (6.6) | 0.858 |
| Chronic obstructive lung disease | 13 (8.4) | 9 (6.0) | 0.402 |
| Neoplasia | 37 (24.0) | 19 (12.6) | 0.01 |
| Chemotherapy | 6 (3.9) | 5 (3.3) | 0.784 |
| Menopause, n = 189 (%)* | 57 (70.4) | 72 (66.7) | 0.588 |
| Prostate benign hypertrophy, n = 116 (%)# | 48 (64.9) | 27 (62.8) | 0.822 |
| No risk factor One risk factor Two or more risk factors | 7 (4.5)4 (2.6)146 (94.8) | 20 (13.2)24 (15.9)106 (70.2) | 0.007<0.0001<0.0001 |
*: Univariate analysis was performed in women. #: Univariate analysis was performed in men.