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. 2019 Oct 24;49(5):1582–1589. doi: 10.3906/sag-1901-15

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Copyright © 2019 The Author(s)

This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use and redistribution provided that the original author and source are credited.

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H&E staining of sections from all experimental groups. Control group livers showed normal radially extending hepatocytes. DM group showed decreased radial configuration of hepatocytes and vacuolation. Low-dose losartan group showed little improvement in contrast with diabetes group. Mid-dose losartan group showed similar configuration to control group. High-dose losartan showed increased number of Kupffer cells and infiltration compared to other losartan-treated groups (20× magnification).