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The existence of RP and MTHFR mutation.
| Positive | Negative | Total | P and X2 | |
| Control | 9 (14.7%) | 52 (85.3%) | 61 (100%) | P < 0.05X2 = 15.97 |
| MTHFR heterozygous | 22 (8%) | 253 (92%) | 275 (100%) | |
| MTHFR homozygous | 14 (26.9%) | 38 (73.1%) | 52 (100%) | |
| Total | 45 (11.6%) | 343 (88.4%) | 388 (100%) |
