Table 4.
Comparisons of pulmonary neuroendocrine tumors (PNET) and other groups with ROC analysis in terms of progastrin-releasing peptide (ProGRP), neuron-specific enolase (NSE), adjusted NSE, chromogranin A (CgA), and squamous cell carcinoma antigen 1 (SCCA1) values.
| PNET (n = 23) | NSCLC (n = 28) | Benign (n = 25) | Healthy (n = 24) | P | |
| CgA (ng/mL) | 1644.5 (946.9–1644.5) | 1363.4 (1068.1–1916.0) | 1554.4 (1034.7–1900.8) | 1675.8 (1419.2–2786.5) | >0.05 |
| ProGRP (pg/mL) | 151.8 (39.8–2563.0) | 56.8 (37.9–78.5) | 45.9 (34.5–59.) | 47.9 (32.9–62.6) | 0.006* |
| NSE (ng/mL) | 29.0 (12.0–147.4) | 24.3 (15.8–52.8) | 22.0 (15.5–33.0) | 13.2 (11.9–22.5) | 0.015# |
| NSE adjusted (ng/mL) | 17.1 (9.6–135.1) | 13.8 (9.9–28.6) | 11.3 (7.3–17.8) | 9.8 (8.6–11.6) | 0.009& |
| SCCA1 (pg/mL) | 27.8 (19.6–46.06) | 32.9 (21.6–43.4) | 34.5 (16.9–75.3) | 36.8 (24.7–58.4) | >0.05 |
AUC: Area under the curve; PPV: positive predictive value; NPV: negative predictive value; NS: not significant. The ProGRP and SCCA1 threshold values are given in pg/mL, whereas the CgA and adjusted NSE threshold values are given in ng/mL.