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. 2019 Jun 18;49(3):914–921. doi: 10.3906/sag-1901-231

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Copyright © 2019 The Author(s)

This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use and redistribution provided that the original author and source are credited.

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Pemetrexed (folic acid metabolism inhibitor) effect. PTX (0.25–20 μM, low dose effect; 125 μM–2.5 mM, high dose effect) cell proliferations were measured in real time for 7 h. A nontoxic dose was selected for HUVECs for combined effect. When the trend change between recurrent measurements was analyzed using Mauchly’s sphericity test, the 5 and 2.5 mM PTX groups were significantly higher than the control group (P < 0.05).