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. Author manuscript; available in PMC: 2020 Feb 13.
Published in final edited form as: Biochemistry. 2019 Apr 17;58(17):2260–2268. doi: 10.1021/acs.biochem.8b00939

Scheme 1.

Scheme 1.

Two Mechanisms for Inhibition of an Enzyme by an Inhibitor:Substrate Complexa

aMechanism 1 is inhibition by pure substrate depletion. Mechanism 2 is inhibition by substrate depletion and inhibition of the enzyme by the inhibitor:substrate complex.