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. 2020 Feb 13;9:e52378. doi: 10.7554/eLife.52378

Figure 4. Mice lacking both β1 and β4 spectrin in PNS sensory neurons have motor dysfunction and impaired action potential conduction.

Figure 4.

(A) Avil-cre;SptbF/F;Sptbn4F/F mice have a hindlimb clasping reflex. (B) Footprint assay in 6 week-old SptbF/F;Sptbn4F/F and Avil-cre;SptbF/F;Sptbn4F/F mice. (C) Accelerating rotarod test performed on 6 week-old mice. SptbF/F;Sptbn4F/F, N = 8; Avil-cre; SptbF/F;Sptbn4F/F, N = 10. Data are mean ± SEM, ***p=7.17995E-09. (D) Tail immersion test performed on 6 week-old mice. SptbF/F, N = 8; Avil-cre;SptbF/F;Sptbn4F/F, N = 10. Data are mean ± SEM, p=0.2011. (E) Representative CAPs recorded from 5 week-old SptbF/F;Sptbn4F/F (black) and Avil-cre;SptbF/F;Sptbn4F/F (red) dorsal roots. (F) Conduction velocities recorded from 5 week-old mice. SptbF/F;Sptbn4F/F, N = 3 mice, 12 dorsal roots. Avil-cre;SptbF/F;Sptbn4F/F, N = 3 mice, 11 dorsal roots. Data are mean ± SEM. ***p=2.76334E-14.

Figure 4—source data 1. Statistical summary for Figure 4C,D,F.