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Mice lacking β1 spectrin have normal nodes of Ranvier. Mice lacking β4 spectrin have normal nodes of Ranvier due to compensation by a β1 spectrin/AnkR protein complex. Mice lacking all nodal β spectrins cluster Nav channels during early development. However, with increasing age these mice lose nodal Nav channels, Ankyrins, and NF186, and show an axon injury response including altered membrane organization.
