Figure 5. Rapid cell cycle of embryonic stem cells are frequently growth-limited.

(A) Cycle length distribution of data (black) and growth-progression model (purple). (B) Measured (black) and modeled (purple) correlation pattern using the growth-progression model. (C) Model evidences of the BAR model, version numbering as in Figure 2B. (D) Proportion of simulated cells limited by growth or progression. Data from Filipczyk et al. (2015) reanalyzed for cell-cycle duration.

Figure 5—figure supplement 1. Growth-progression and BAR models fitted to embryonic stem cell data.

(A,B) Embryonic stem cell data (black) provided by Filipczyk et al. (2015) and model fit (purple) of the two replicate experiments not shown in Figure 5A–C. showing (A) distribution of cycle lengths with median and interquartile range and (B) correlation pattern with bootstrap 95%-confidence bounds. (C) Proportion of simulated embryonic stem cells limited by growth or progression using the growth-progression model showing mean of 100 simulations. (D, E) As Figure 4—figure supplement 1G–J but for embryonic stem cells. Model V (orange dots) is favored by short-ranged ancestral and extended intra-generational correlations in all three replicates (for legend see Figure 4—figure supplement 1I, J).