Figure 9. An example workflow for simulating canonical pyramidal-interneuron gamma (PING) rhythms (Lee and Jones, 2013; see Gamma Rhythms Tutorial text for details).

(A) Here we are using the default HNN network configuration (with some parameter adjustments as shown in panel B) and we are not directly comparing the waveform to data, so begin with Step 3: activate the local network. Motivated by prior studies on PING mechanisms (see text), in this example PING rhythms were simulated by driving the pyramidal neuron somas with noisy excitatory synaptic input following a Poisson process. The parameters defining this noisy drive are viewed and adjusted through the Set Parameters button as shown, see text and Materials and methods for parameter details. This parameter set for this example is provided in the ‘gamma_L5weak_L2weak.param’ file. In this example, all synaptic connections within the network are turned off (synaptic weight = 0), except for reciprocal connections between the excitatory (AMPA only) and inhibitory (GABAA only) cells within the same layer. The local network connectivity can be viewed and adjusted through the Set Network Connection button or pull down menu, as shown in (B). (C) Step 4: running the simulation with the ‘Run Simulation’ button, shows that a ~ 50 Hz gamma rhythm is produced in the current dipole signal (middle dipole time trace; bottom time-frequency representation). The black histogram at the top displays the noisy excitatory drive to the network. (D–F) Step 5: additional network features, including cell spiking responses, somatic voltages, and layer specific power spectral density plots as shown can be visualized through the ‘View’ pull down menu.