Patients CYP2C19 genotyped receiving/not receiving VCZ (n=263) |
No. (%) |
Did not receive VCZ |
44 (16.7) |
Received VCZ |
219 (83.3) |
Reason for VCZ prescribing (n=219) |
No. (%) |
Treatment |
17 (7.8) |
Prophylaxis |
202 (92.2) |
Followed CYP2C19-guided prophylaxis protocol |
No. (%) |
All genotype groups (n=202) |
176 (87.1) |
CYP2C19*1/*17 group (n=58) |
46 (79.3) |
CYP2C19*17/*17 group (n=5) |
4 (80) |
Reason for not following the protocol |
No. (%) |
Weight‒obese dosing |
1 (3.9) |
Prior VCZ pharmacokinetics |
1 (3.9) |
Patient died before CYP2C19 returned |
1 (3.9) |
Elevated liver enzymes |
3 (11.5) |
Unknown |
6 (23.1) |
Patient discharged from hospital before CYP2C19 returned |
14 (53.8) |