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. Author manuscript; available in PMC: 2021 Feb 1.
Published in final edited form as: FASEB J. 2019 Dec 23;34(2):2392–2407. doi: 10.1096/fj.201902227R

Figure 5. miR182 deficiency protects Mir182ΔM/ΔMRbpjΔM/ΔM dKO mice from bone erosion in inflammatory arthritis.

Figure 5.

A. TRAP staining of histological sections of tarsal joints (Scale bar: 200 μm) and B. histomorphometric analysis of the tarsal joint sections obtained from the indicated mice that developed K/BxN serum-induced arthritis. ES/BS, erosion surface per bone surface. Oc.S/BS, osteoclast surface per bone surface; N.Oc/B.Pm, number of osteoclasts per bone perimeter. n = 5 per group. Data are mean ± SEM. **p < 0.01; n.s., not statistically significant. C. Time course of joint swelling of inflammatory arthritis developed in Ctrl, Mir182ΔM/ΔM, RbpjΔM/ΔM, and Mir182ΔM/ΔMRbpjΔM/ΔM dKO mice. For each mouse, joint swelling was calculated as the sum of measurements of joint thickness of two wrists and two ankles. n = 5 per group. Joint swelling is represented as the mean ± SD for each group. n.s., not statistically significant.