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. Author manuscript; available in PMC: 2021 Feb 1.
Published in final edited form as: FASEB J. 2019 Dec 23;34(2):2691–2702. doi: 10.1096/fj.201900048R

Figure 6.

Figure 6.

Adhesion of neutrophils to the corresponding endothelium is similar between human and mouse. TNF-α activation and treatment with the PKCδ-TAT peptide inhibitor (PKCδ-i) similarly impacts adhesion of human (A) or mouse (B) neutrophils to their corresponding endothelial cells. The impact of TNF-α activation of endothelial cells and treatment with the PKCδ-TAT peptide inhibitor was most pronounced in vessels with low flow. Mouse neutrophils adhered significantly near bifurcations where the flow patterns are altered. Overall, the adhesion patterns of neutrophils to endothelial cells in human is not significantly different from that of mouse (C) (N=4, Mean ± SEM, two-way ANOVA, * p<0.05, ** p<0.01, *** p<0.001).