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. Author manuscript; available in PMC: 2021 Feb 1.
Published in final edited form as: FASEB J. 2019 Dec 23;34(2):2691–2702. doi: 10.1096/fj.201900048R

Figure 7.

Figure 7.

Adhesion molecules are differentially expressed in human and mouse cells in response to TNF-α mediated activation. While the adhesion pattern of microparticles coated with anti-E-selectin, anti-VCAM-1 or anti-JAM-C was similar between human (A) and mouse cells (B), adhesion of microparticles coated with anti-ICAM-1 to human cells was significantly higher as compared to mouse cells; i.e. ICAM-1 is not upregulated on activated mouse endothelial cells (B). Treatment with the PKCδ-TAT peptide inhibitor (PKCδ-i) reduced the upregulated adhesion of E-selectin, ICAM-1 and VCAM-1 in human cells as well as E-selectin and VCAM-1 in mouse cells to their corresponding background levels. (N=3, Mean ± SEM, one-way ANOVA, ** p<0.01, and *** p<0.001)