Table I.

Summary of tumor types and models demonstrating blood vessel co-option, angiotropism, or pericyte-like migratory patterns by cancer cells.

Cancer type
		Intracranial transplantation	Intracardiac transplantation	Intracarotid transplantation	Intravenous transplantation	Orthotopic transplantation	Genetically engineered mice	Zebra fish model	Chicken CAM & metastasis assay	Brain slice/tumor cell co-culture	Endothelial cell/tumor cell co-culture	Ear tissue invasion assay	A
Glioma	C6 murine (rat)													[39]
	Cdkn2a−/−;hEGFRvIII murine													[33]
	CNS-1 murine (rat)													[42]
	GL26 murine										√			[17, 32]
	GL261 murine													[41, 42]
	Olig2+ (Olig2cre/+;Trp53fl/fl;hEGFRvIII) murine													[33]
	Olig2− (Olig2cre/cre;Trp53fl/fl;hEGFRvIII) murine													[33]
	D54 human GBM													[31, 33]
	G55 human GBM													[38, 40]
	HF2303 human										√			[32]
	MGG8 human GBM													[33]
	SF10417 human oligodendroglioma													[33]
	U373 human GBM													[15]
	U87 human GBM													[15]
Melanoma	B16F10 murine				√				√		√			[17, 36, 47, 51, 53]
	D4M3A murine													This publication
	Hcmel12 murine					√						√	√	[48]
	Hcmel31 murine											√		[48]
	HGF-CDK4(R24C)						√							[48]
	K1735M2 murine		√											[36]
	530 human			√										[24]
	A2058 human			√										[26]
	A7 human		√											[36]
	C8161 human					√		√	√		√			[25, 50, 52, 53, 54, 55]
	M14 human			√										[24]
	MaMel15 human											√		[48]
	MaMel48 human											√		[48]
	MaMel65 human											√		[48]
	MDA-MB-435 human			√										[26]
	Mel57 human			√										[24, 46]
	MZ7-MEL human											√		[48]
	OMM 2.3 human uveal							√			√			[52]
	OMM 2.5 human uveal										√			[52]
Breast	4T1 murine adenocarcinoma		√		√	√		√	√					[6, 36, 51]
	MAT-B-III murine (rat)				√									[47]
	RBA murine (rat) adenocarcinoma													[39]
	MDA-MB-231 human cells		√											[36]
	MDA-MB-231-BrM human		√								√			[35, 36, 42, 44, 45]
	MDA-MB-231-LM human				√	√								[6, 44]
	HCC1954-LCC1 human		√											[44]
	HMLE human							√	√					[51]
Lung	393N1 murine adenocarcinoma		√											[44]
	Lewis murine				√									[39]
	H2030-BrM human adenocarcinoma		√								√			[35, 44]
	HTB177 human			√										[26]
Liver	Hep3B-hCG human					√								[49]
Colon	C26 murine				√									[6, 47]
	HT25 human				√									[47]
	HT29 human colorectal					√								[13]
Fibrosarcoma	HT1080 human				√									[47]
Prostate	PC-3 human								√		√			[53]
Renal	RENCA murine				√									[6]