Table 1.
Summary of the effect of Hcrt-r1 blockade on alcohol-related behaviors
| Measure | Ligand (dose) | Findings | References | |
|---|---|---|---|---|
| Int. | SB334867 (20 mg/kg) | FR Alcohol SA | ↓ | Lawrence et al., 2006 |
| SB334867 (20 mg/kg) | FR Water SA | – | ||
| SB334867 (10 & 20 mg/kg) | FR Alcohol SA | ↓ | Richards et al., 2008 | |
| SB334867 (10 & 20 mg/kg) | FR Sucrose SA | – | ||
| SB334867 (10 mg/kg) | FR Sucrose SA | – | Cason & Aston-Jones, 2013 | |
| SB334867 (20 & 30 mg/kg) | FR Sucrose SA | ↓ | ||
| SB334867 (5 mg/kg) | FR Alcohol SA | ↓ | Jupp et al., 2011 | |
| SB334867 (5 mg/kg) | FR Sucrose SA | ↓ | ||
| SB334867 (5 mg/kg) | PR Alcohol SA | ↓ | ||
| SB334867 (5 mg/kg) | PR Sucrose SA | – | ||
| SB334867 (10 & 30 mg/kg) | 2BC Alcohol SA | – | Anderson et al., 2014 | |
| SB334867 (10 & 30 mg/kg) | PR Alcohol SA | – | ||
| SB408124 (1, 10, & 30 mg/kg) | FR Alcohol SA | – | Shoblock et al., 2011 | |
| SB334867 (30 mg/kg) | 2BC Alcohol SA | ↓ | Moorman & Aston-Jones, 2009 | |
| Reinst. | SB334867 (20 mg/kg) | Alcohol cue | ↓ | Lawrence et al., 2006 |
| SB334867 (5 & 10 mg/kg) | Stress | ↓ | Richards et al., 2008 | |
| Pref. | SB334867 (30 mg/kg) | 2BC | ↓ | Moorman & Aston-Jones, 2009 |
Int.: Intake
Reinst.: Reinstatement
Pref.: Preference
2BC: 2-bottle choice
FR: Fixed Ratio
PR: Progressive Ratio
SA: Self-administration
–
: no effect
↓
: decrease