Table 2.

Results of logistic regression models of NCI on biomarkers and sex, controlling for HIV viral load.

Predictors	N	OR (95% Cl)a	P-value
Plasma IFN-γ	81	1.71 (0.88, 3.33)	0.12
Sex		0.77 (0.31, 1.94)	0.58
HIV VL Detectable		1.27 (0.46, 3.49)	0.65
Plasma CXCL10	99	13.4(1.23,145.52)	0.021*
Sex		0.64 (0.27, 1.51)	0.31
Plasma CXCL10*Sex Interaction		0.03 (0.002, 0.51)	0.016*
HIV VL Detectable		1.12 (0.37, 3.40)	0.84
Plasma IL-6	130	2.85 (1.37, 5.91)	0.005**
Sex		0.87 (0.40, 1.87)	0.72
HIV VL Detectable		1.29 (0.58, 2.87)	0.53
Plasma TNF-α	127	1.90 (1.09,3.33)	0.025*
Sex		0.93 (0.43, 1.99)	0.85
HIV VL Detectable		1.19 (0.53, 2.64)	0.68
Plasma CCL2	100	0.45 (0.05, 4.25)	0.49
Sex		0.79 (0.34, 1.84)	0.59
HIV VL Detectable		1.75 (0.69, 4.46)	0.24
Plasma CXCL8	142	1.82 (0.40, 8.19)	0.44
Sex		1.03 (0.51, 2.08)	0.94
HIV VL Detectable		0.95 (0.45, 1.99)	0.89
CSF CXCL10	44	0.88 (0.16, 4.70)	0.88
Sex		0.95 (0.26, 3.39)	0.93
HIV VL Detectable		1.03 (0.19, 5.46)	0.97
CSF IL-6	41	0.13 (0.001, 13.4)	0.39
Sex		1.02 (0.24, 4.31)	0.98
HIV VL Detectable		1.46 (0.30, 7.00)	0.64
CSF TNF-α	46	0.45 (0.04, 5.77)	0.54
Sex		1.04 (0.28, 3.86)	0.95
HIV VL Detectable		1.22 (0.27, 5.43)	0.78
CSF CCL2	41	0.38 (0.004, 39.3)	0.68
Sex		1.66 (0.45, 6.13)	0.45
HIV VL Detectable		0.93 (0.22, 3.91)	0.92
CSF CXCL8	56	0.32 (0.01, 8.61)	0.50
Sex		0.74 (0.23,2.33)	0.60
HIV VL Detectable		1.30 (0.36, 4.74)	0.69

Notes:

^aThe odds ratio > 1 indicates higher odds of cognitive impairment, and the odds ratio < 1 indicates lower odds of cognitive impairment. For biomarkers, the odds ratio is measured per 1 unit increase on log10 scale. For sex, the odds ratio compares men to women (reference group). For HIV viral load, the odds ratio compares detectable to undetectable (reference group).

^bFor the interaction, the provided estimate are a ratio of odds ratios.

^*P<0.05

^**P<0.01.

OR = odds ratio; CI = confidence interval.