Table 1.

Effects of PPAR Antagonists, Tesaglitazar and Fenofibrate, on 24-hr and 6 hr 2BC Drinking

		HDID-1			HS/NPT
		Baseline	Habituation	Treatment	Baseline	Habituation	Treatment
24-hr intake (g/kg)
	mg/kg
Vehicle	0	1.96 ± 0.59	3.12 ± 1.13	2.82 ± 1.19	1.22 ± 0.17	2.28 ± 0.68	1.46 ± 0.19
Tesaglitazar	0.75	3.53 ± 1.04	3.35 ± 0.92	3.57 ± 0.96	1.60 ± 0.32	1.28 ± 0.32	1.12 ± 0.14
Tesaglitazar	1.5	2.05 ± 0.42	3.44 ± 1.28	2.47 ± 0.34	1.22 ± 0.21	1.83 ± 0.41	1.11 ± 0.13
Fenofibrate	75	1.73 ± 0.47	2.89 ± 1.02	2.91 ± 0.93	2.17 ± 0.91	2.92 ± 1.28	1.98 ± 0.54
Fenofibrate	150	3.87 ± 1.46	2.83 ± 1.11	3.28 ± 1.07	2.01 ± 0.87	1.35 ± 0.31	1.35 ± 0.22
6-hr intake (g/kg)
	mg/kg
Vehicle	0	0.61 ± 0.20	1.24 ± 0.51	1.19 ± 0.52	1.18 ± 0.52	1.06 ± 0.52	0.75 ± 0.15
Tesaglitazar	0.75	0.46 ± 0.24	1.35 ± 0.40	1.76 ± 0.48	0.44 ± 0.26	0.66 ± 0.15	0.50 ± 0.10
Tesaglitazar	1.5	0.62 ± 0.26	0.75 ± 0.23	1.38 ± 0.32	0.35 ± 0.19	0.77 ± 0.26	0.43 ± 0.08
Fenofibrate	75	1.30 ± 0.54	1.33 ± 0.45	1.25 ± 0.42	1.13 ± 0.73	1.45 ± 0.78	0.73 ± 0.24
Fenofibrate	150	2.35 ± 1.05	1.23 ± 0.51	1.52 ± 0.55	1.03 ± 0.24	0.56 ± 0.22	0.65 ± 0.14

Means ± SEM shown