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. 2019 Nov 4;39(7):1557–1571. doi: 10.1038/s41388-019-1085-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — DEPTOR expression is decreased in prostate tumor tissues compared with their corresponding tumor-adjacent normal tissues. a, b The expression of DEPTOR protein is significantly reduced in human prostate cancer tissues. Prostate tissue microarrays containing 59 tumor tissues (T) and their corresponding tumor-adjacent normal tissues (N) were stained for DEPTOR expression. Representative images of DEPTOR staining are shown (a). Scale bars: 100 μm. Each IHC picture is shown in better resolution at the lower left corner. Scale bars: 30 μm. DEPTOR expression was evaluated using the IRS system according to the staining intensity and the percentage of positive cells (b). The Wilcoxon rank sum test was utilized to assess the DEPTOR expression from 59 pairs of prostate tissue samples. p = 0.041. c DEPTOR transcript is significantly reduced in primary prostate tumors compared with normal tissues from TCGA database. p < 0.001. d The association of DEPTOR expression in prostate tumor tissues from 89 patients with Gleason score