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. 2019 Nov 4;39(7):1557–1571. doi: 10.1038/s41388-019-1085-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Deptor knockout induces prostate tumorigenesis triggered by Pten heterozygous loss via the activation of mTORC1 and mTORC2 signaling in mice. a Deptor knockout causes prostate tumorigenesis triggered by Pten heterozygous loss. Representative images of the mice and prostate glands from three pairs of Deptor^+/+;Pten^+/− and Deptor^−/−;Pten^+/− littermate mice. b, c Excessive proliferation of epithelial cells in prostate cancer tissues from Deptor^−/−;Pten^+/− mice. The prostate tissues from Deptor^+/+;Pten^+/− and Deptor^−/−;Pten^+/− mice were sectioned and subjected to H&E staining (b) and Ki67 staining (c). d Deptor deletion activates mTORC1 and mTORC2 signaling during prostate tumorigenesis. The prostate tissues from Deptor^+/+;Pten^+/− and Deptor^−/−;Pten^+/− mice were sectioned and subjected to immunohistochemical staining with the indicated antibodies. The staining quantification was determined by IHC scoring using an IRS system from at least five random fields of prostate tissue sections. *p < 0.05; **p < 0.01; ***p < 0.001. e A model for DEPTOR suppression of prostate tumorigenesis