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. 2020 Feb 7;11:116. doi: 10.3389/fmicb.2020.00116

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Copyright © 2020 Feng, Bai, Wang, Garcia, Bai, Li, Honda, Nie and Chan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Qualitative diagram of the relationship between CFU and effector functions of macrophages infected with MTB and NTM. See the section “Discussion” in text. For p65-NF-κB activation, phagosome–lysosome fusion, and autophagosome formation, the data are displayed separately for the RGM (M. smegmatis and M. abscessus) and SGM (M. intracellulare, M. avium) plus MTB (different geometrical shapes with various shades of gray) but also combined (overlaying red-dashed triangles). While it is more difficult to generalize the relative induction of apoptosis with the NTM species, MTB induced the least amount of apoptosis and apoptotic phenotypic markers in the infected macrophages. CFU, colony forming units; NF-κB, nuclear factor kappa B; M. sm, M. smegmatis; M. ab, M. abscessus; M. in, M. intracellulare; M. av, M. avium; MTB, M. tuberculosis.