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. 2020 Feb 7;11:124. doi: 10.3389/fmicb.2020.00124

FIGURE 1.

FIGURE 1

Herpesviruses use a variety of strategies to manipulate ISGs. Viral proteins can interfere with protein expression and stability of ISGs, inhibit signalling pathways exerted by ISGs or, in some cases, exploit ISGs for their own benefit. Viral proteins are depicted in red, while ISGs are shown in green. Abbreviations: HSV-1, herpes simplex virus type 1; HCMV, human cytomegalovirus; KSHV, Kaposi’s sarcoma-associated herpesvirus; IFI16, gamma-interferon-inducible protein 16; STING, stimulator of interferon genes; IFN, interferon; ZAP, zinc finger CCCH-type antiviral protein; IFIT3, interferon-induced protein with tetratricopeptide repeats 3; NMI, N-myc-interactor; STAT1/2, signal transducer and activator of transcription 1/2; ISG15, interferon-stimulated gene 15; IRF, interferon regulatory factor; OASL, 2′-5′-Oligoadenylate synthetase like; OAS1, 2′-5′-Oligoadenylate synthetase 1; RNase L, ribonuclease L.