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(A) Schematic diagram of the FUS domains showing the SYQG rich region, the RNA recognition motif and three arginine-glycine-glycine (RGG) domains. (B) Predicted structure of Shank1a GQ and PSD-95 GQ2 (Stefanovic et al., 2014; Zhang et al., 2014). C to U mutations indicated with arrows and dashed circles, and 2-AP substitutions are denoted by solid circles.
