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. 2020 Feb 13;9(2):18. doi: 10.1038/s41389-020-0201-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Tubes formed by HUVECs when treated with conditioned media from PERK and PAM knockdown LN229 cells using two different shRNAs along with nontarget control. Scale bars: 500 µm. b Plots showing number of junctions and meshes formed by HUVECs when treated with conditioned media from PERK and PAM knockdown LN229 cells. The data are normalized to the shNT control and is represented as a mean of three independent biological replicates ± SEM (t test with p value < 0.05*, <0.01** and <0.001***). c Vesicles isolated from the conditioned media of LN308 cells cultivated under hypoxia for 24 h. Vesicles (from cells with either shNT or shPAM-1) stained with immunolabeled gold (Au) particles for PAM detection. Red arrows indicate Au-label. Scale bars: 100 nm.