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. 2020 Feb 13;11:822. doi: 10.1038/s41467-020-14551-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Hierarchical clustering of gene expression profiles distinguishing stromal and tumour cells from chemo-naïve OCM.38a. b Principal component analysis integrated with pathway analysis showing subpopulations of tumour and stromal cells. c Heat map showing mean expression levels of selected genes in OCM.38a tumour and stromal sub-populations. d Scatter plots of G1 score versus G2/M score for individual cells within the TAa/TAb sub-populations. e Gene ontology analysis of overdispersed genes in stromal and tumour cells. f Network analysis of overdispersed genes in tumour cells. g Heat map of overdispersed genes showing that TAb cells expressing higher levels of mitotic genes and have high G2/M scores. Source data for panels b–e and g are provided as a Source Data file.