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. 2020 Feb 13;10:2569. doi: 10.1038/s41598-020-59541-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The long-term non-adjustive condition of light–dark cycles led to increased mortality. (A) Kaplan–Meier survival curves of mice kept under the three conditions. (B) The log-rank test was used to compare the Kaplan-Meier curves for the indicated conditions. The P values were adjusted by Bonferroni’s correction. The Cox proportional hazard regression model stratified by light conditions was used to obtain the hazard ratio (HR) and the associated 95% confidence interval (95% CI). n.s. = 0.6684.