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. 2020 Feb 13;10:2542. doi: 10.1038/s41598-020-59011-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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LID assessment of D5 KO mice. Mice were treated with L-DOPA/Benserazide (L-DOPA 3 mg/kg, Benserazide 10 mg/kg, i.p.) daily and AIMs determined starting at 20 min post injection. Total AIMs scores (A,D,G) ALO score (A,E), LOC score (B,F) and were determined and plotted as summarized score or as time course at 20 min intervals for 2 hours after L-DOPA injection (N = 10–12). SKF83959 (0.2 mg/kg, i.p.) was injected instead of L-DOPA and total AIMs, ALO and ROT scores assessed (G–I), (N = 6). Graphs show mean values +/− SEM. Statistical analysis was performed using Student’s t-test (A (p > 0.05), D, G (p < 0.05)) and 2-way ANOVA (Effect of genotype (B): F(1, 120) = 10.6, p = 0.0015; (C): F(1, 120) = 3.45, p > 0.05; (E): F(1, 120) = 41.5, p < 0.0001; (F): F(1, 120) = 15.26, p = 0.0002; (H): F(1, 120) = 23.58, p < 0.0001; (I): F(1, 120) = 13.4, p = 0.0004). Sidak’s multiple comparisons post-test (**P < 0.01;*P < 0.05).