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. 2020 Feb 13;10:2542. doi: 10.1038/s41598-020-59011-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Markers of CIN activation are altered in Drd5-KO mice. Immunohistochemical analysis of coronal striatal slices from WT and Drd5-KO mice and quantification thereof after chronic L-DOPA/Benserazide (3 mg/kg/10 mg/kg, i.p.) using pERK antibody (A–C), pS6 (D–F), pan-pPKA substrate (G,H) and pHisH3 antibodies (I,J). Scale bars 100 μm. N = 10–12. Data are means +/− S.E.M. Statistical analysis was performed using one-way ANOVA and Dunnett’s mupltiple comparisons post-test (****P < 0.0001; **P < 0.01; *P < 0.05).